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Evidence to Improve Care

DNA Methylation-Based Classification for Central Nervous System Tumours

 

Final Recommendation

  • Ontario Health, based on guidance from the Ontario Health Technology Advisory Committee, recommends publicly funding DNA methylation–based classifier tests as an adjunct tool for the classification of central nervous system tumours when substantial clinical uncertainty remains after conventional testing.

Read the final recommendation report


Central nervous system tumours occur when abnormal cells form in the brain and/or spinal cord. Treatment strategy starts with classifying the tumour according to its characteristics – including size and malignancy (tendency to grow and spread). Recently, a test called the DNA methylation–based classifier test has been used in addition to established tests to help with tumour classification, especially tumours that have been difficult to classify using other methods.

This health technology assessment looked at how safe, effective, and cost-effective DNA methylation– based classifier testing is for central nervous system tumour classification. It also looked at the budget impact of publicly funding DNA methylation–based classifier tests.

Read the full health technology assessment report for more information.

DNA Methylation-Based Classification for Central Nervous System Tumours : A Health Technology Assessment (PDF)
November 2025

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The Ministry of Health is currently reviewing this recommendation.

The Ministry of Health has provided the following response: The Ministry has a standardized process in place to review health technology assessments and funding recommendations. This takes into consideration Ministry priorities, implementation options, the need for consultation with impacted stakeholders, and funding considerations.



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